Our Publications

Full list of publications can be accessed here.

Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response

Kanishk Jain*, Pata-Eting K. Tchara, Abid Khan, Amanuel B. Mengistalem, Aidan P. Holland, Christopher N. Bowman, Matthew R. Marunde, Tiffany A. Engel, Irina K. Popov, Spencer W. Cooke, Krzysztof Krajewski, Michael-Christopher Keogh, Jean-Philippe Lambert, and Brian D. Strahl*. Nucleic Acids Research. 2025 July; 53(12) gkaf666 https://doi.org/10.1093/nar/gkaf666

*denotes co-corresponding authors

H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

Geoffrey C. Fox, Karl F. Poncha, B. Rutledge Smith, Lara N. van der Maas, Nathaniel N. Robbins, Bria Graham, Jill M. Dowen, Brian D. Strahl*, Nicolas L. Young*, and Kanishk Jain*. J. Biol. Chem. 2024 Aug; 300(8) 107527.

An acetylation-mediated chromatin switch governs H3K4 read-write capability

Kanishk Jain, Matthew R. Marunde, Jonathan M. Burg, Susan L. Gloor, Faith M. Joseph, Karl F. Poncha, Zachary B. Gillespie, Keli L. Rodriguez, Irina K. Popova, Nathan W. Hall, Anup Vaidya, Sarah A. Howard, Hailey F. Taylor, Laylo Mukhsinova, Ugochi C. Onuoha, Emily F. Patteson, Spencer W. Cooke, Bethany C. Taylor, Ellen N. Weinzapfel, Marcus A. Cheek, Matthew J. Meiners, Geoffrey C. Fox, Kevin E. Namitz, Martis W. Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S. Cosgrove, Nicolas Young, Michael-C Keogh, and Brian D. Strahl. eLife. 2023 May 12:e82596.

Note: This study was published in eLife through the conventional peer-review method.

Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions

Kanishk Jain, Caroline S. Fraser, Matthew Marunde, Madison M. Parker, Cari Sagum, Jon Burg, Nathan Hall, Irina Popova, Keli Rodriguez, Anup Vadiya, Krzysztof Krajewski, Michael-Christopher Keogh, Mark T. Bedford, and Brian D. Strahl.

PRMT7: a unique member of the protein arginine methyltransferase family

Kanishk Jain and Steven G. Clarke. Archive of Biochemistry and Biophysics. 2019 Apr 665: 36-45.

Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases

Kanishk Jain, Cyrus Y. Jin, and Steven G. Clarke. PNAS USA. 2017 Sep 114(38):10101-10106.

Protein arginine methyltransferase product specificity is mediated by distinct active-site architectures

Kanishk Jain, Rebeccah A. Warmack, Erik W. Debler, Andrea Hadjikyriacou, Pete Stavropoulos, Günter Blobel, and Steven G. Clarke. J. Biol. Chem. 2016 Aug 291(35): 18299-308.

A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase

Erik W. Debler, Kanishk Jain, Rebeccah A. Warmack, You Feng, Steven G. Clarke, Gunter Blobel, and Pete Stravropoulos. .” PNAS USA. 2016 Feb 113(8): 2068-73.